Xəbərlər AMEA Biologiya və tibb elmləri bölməsinin rəsmi jurnalı
Study Of The Azerbaijan Population By STR Markers: II. Interpopulation Analysis On The Basis of STR Markers’ Allele Structure
N.Sh. Mustafayev, A.Ch. Mammadov, E.R. Mammadov, F.R. Huseynova, A.B. Hasanov, I.M. Huseynova

Institute of Molecular Biology & Biotechnologies, Azerbaijan National Academy of Sciences

Scientific-Practical Unit of “Anatomical Pathology and Forensic Medical Examination”,
Ministry of Health of the Republic of Azerbaijan

Azerbaijan population consisting of 302 individuals was studied using 15-STR markers constituting the main set of human identification, and for each STR locus the forensic and population-genetic parameters were determined. Along with the other parameters, the calculated P-values (PHWE) for the accuracy of the Hardy-Weinberg equilibrium (HWE) tests showed that for our population this parameter had a statistically significant value (PvWA=0.0006) only for the vWA locus. The values of parameters for a set of 15 STR loci such as the combined power of exclusion (CPE=0.99999935), combined power of discrimination (CPD=0.9999999999999999965), combined paternity index (CPI=1466339.18) and the probability of paternity (PP=0.99999932) showed that given set of loci can be confidently used in solving of identification problems for the studied population. Primary assessments revealed that for our population the D21S11, D2S1338, D18S51 and FGA STR markers are more informative. In addition, comparative analysis of our population with 14 world populations based on the allelic composition of STR markers, allelic frequencies and basic population-genetic parameters have established that there are some degree of differences in the allelic structure of individual loci and the frequencies of the identified alleles between the compared populations. Significant differences are observed both in the region of the most frequent major and in the region of low-frequency minor alleles of STR markers.

STR loci, combined power of exclusion, combined power of discrimination, combined paternity index, probability of paternity, interpopulation comparative analysis