Xəbərlər AMEA Biologiya və tibb elmləri bölməsinin rəsmi jurnalı
Impact Of Fluoxetine On Aminergic Indexes Of Anxiety State In Rats With Different Phenotypes Of The Nervous System
Kh.Yu. Ismailova, M.B. Madjidi, A.L. Jalilova

Institute of Physiology named after A.I. Garayev, ANAS

Islamic Azad University, Islamic Republic of Iran

    Biochemical analysis after fluoxetine administration revealed predominant downregulation of 5-HT accompanied with upregu­lation of NA in the hypothalamus in the ER animals. In contrast, in the ET rats significant down­regulation of 5-HT accompanied by significant upregulation of DA, while in the frontal cortex of these animals significant upregulation of 5-HT with reciprocal downregulation of DA, involved in anxiety state control and being prominent regulator of motor activity, was noticed. So, it is proposed that fluoxetine upregulates neurochemical indexes of anxiety state due to engagement of both systems of 5-HT and catecholamine which in this case act as reciprocal ones.  

Emotionally-resistance rats, emotionally tolerant rats, the elevated plus-maze, hypothalamus frontal cortex, serotonin, noradrenaline, dopamine