Institute of Physiology named after A.I. Garayev, ANAS
Islamic Azad University, Islamic Republic of Iran
Biochemical analysis after fluoxetine administration revealed predominant downregulation of 5-HT accompanied with upregulation of NA in the hypothalamus in the ER animals. In contrast, in the ET rats significant downregulation of 5-HT accompanied by significant upregulation of DA, while in the frontal cortex of these animals significant upregulation of 5-HT with reciprocal downregulation of DA, involved in anxiety state control and being prominent regulator of motor activity, was noticed. So, it is proposed that fluoxetine upregulates neurochemical indexes of anxiety state due to engagement of both systems of 5-HT and catecholamine which in this case act as reciprocal ones.