Institute of Physiology named after A.I. Garayev, ANAS
It was established that after intramuscular administration of thymalinum the activity of glutamate
decarboxylase increased and activity of GABA-aminotransferase lowered in mitochondria of the brain cells.
Thus, contents of glutamic and aspartic acids decreased, while gamma-aminobutyric acid increased in the
mitochondria of the hypothalamus, cerebellum, visual and motor cortex. Changes in the metabolism of
GABA after the thymalinum action occurred due to the interaction between nervous and immune systems.